IPA | SNARE inhibitor | Probechem Biochemicals

Chemical Structure : IPA

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IPA (Inhibitor of Priming Activity)

货号: PC-73090Not For Human Use, Lab Use Only.

IPA (Inhibitor of Priming Activity) is a small-molecule compound that binds Sec18 (Kd=3.84 uM) and blocks SNARE activation, inhibits vacuole fusion at the SNARE priming stage with IC50 of 50 uM.

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生物&药学活性

IPA (Inhibitor of Priming Activity) is a small-molecule compound that binds Sec18 (Kd=3.84 uM) and blocks SNARE activation, inhibits vacuole fusion at the SNARE priming stage with IC50 of 50 uM.
IPA blocks SNARE priming and competes for phosphatidic acid (PA) binding to Sec18.
IPA more potently and specifically inhibits NSF/Sec18 activity than does N-ethylmaleimide.
IPA is a helpful chemical tool to further elucidate SNARE-priming dynamics.

物理化学性质&存储条件

分子量	394.379
分子式	C22H18O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-methyl-3-(4,5,6-trihydroxy-3-oxo-3H-xanthen-9-yl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

参考文献

1. Sparks RP, et al. J Biol Chem. 2019 Nov 15;294(46):17168-17185.

IPA (Inhibitor of Priming Activity)

生物&药学活性

物理化学性质&存储条件

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IPA (Inhibitor of Priming Activity)

生物&药学活性

物理化学性质&存储条件

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