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首页-小分子抑制剂&激动剂-Others-Other Targets-IP6K1 inhibitor TNP
IP6K1 inhibitor TNP

Chemical Structure : IP6K1 inhibitor TNP

CAS No.: 519178-28-0

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IP6K1 inhibitor TNP (TNP)

货号: PC-63313Not For Human Use, Lab Use Only.

IP6K1 inhibitor TNP is a potent, selective inositol hexakisphosphate kinase IP6K with IC50 of 0.47 uM (IP6K1), does not inhibit either human or yeast Vip/PPIP5K.

规格 价格 库存 数量
5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥2980 In stock
50 mg ￥4780 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IP6K1 inhibitor TNP is a potent, selective inositol hexakisphosphate kinase IP6K with IC50 of 0.47 uM (IP6K1), does not inhibit either human or yeast Vip/PPIP5K.
IP6K1 inhibitor TNP reversibly inhibits InsP7 and InsP8 synthesis in vivo without affecting levels of other inositol phosphates.
IP6K1 inhibitor TNP increases the IGF-1 elicited stimulation of T308 phosphorylation of Akt without influencing p-S473, combination of TNP (10 μM) and SB216763 (1 μM) virtually abolishes adipogenic differentiation of NIH3T3-L1 cells.
IP6K1 inhibitor TNP ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway.
IP6K1 inhibitor TNP also suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia.

物理化学性质&存储条件

分子量 443.39
分子式 C20H16F3N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N6-(4-nitrobenzyl)-N2-(3-(trifluoromethyl)benzyl)-1H-purine-2,6-diamine

参考文献

1. Ghoshal S, et al. Mol Metab. 2016 Aug 21;5(10):903-17.

2. Zhu Q, et al. J Clin Invest. 2016 Nov 1;126(11):4273-4288.

3. Padmanabhan U, et al. J Biol Chem. 2009 Apr 17;284(16):10571-82.

4. Chakraborty A, et al. Cell. 2010 Dec 10;143(6):897-910.

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