IP2015 | Monoamine reuptake inhibitor | Probechem Biochemicals

Chemical Structure : IP2015

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IP2015 (IPED2015, Pudafensine, NS18313)

货号: PC-22148Not For Human Use, Lab Use Only.

IP2015 (IPED2015, Pudafensine, NS18313) is a novel monoamine transport inhibitor with IC50 of 9.5, 72.0 and 3.8 nM for hSET, hNAT and hDAT respectively, inhibits dopamine uptake and binds to DAT.

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生物&药学活性

IP2015 (IPED2015, Pudafensine, NS18313) is a novel monoamine transport inhibitor with IC50 of 9.5, 72.0 and 3.8 nM for hSET, hNAT and hDAT respectively, inhibits dopamine uptake and binds to DAT.
IP2015 inhibits uptake, ex vivo, of 5-HT and noradrenaline to SERT and NET with ED50 values = 49 and >45 mg·kg−1, respectively.
IP2015 (0.1-10 mg/kg) induces spontaneous erections in rats.
The PDE5 inhibitor sildenafil further enhanced the IP2015-mediated increase in intracavernosal pressure.
IP2015 also increases the number of erections in type 2 diabetic db/db mice, increases penile pressure, and in corpus cavernosum strips, and induces concentration-dependent relaxations.

物理化学性质&存储条件

分子量	301.34
分子式	C17H19NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-[(exo-8-azabicyclo[3.2.1]octan-3-yl)oxy]-3-methoxy-chromen-2-one

参考文献

1. Comerma-Steffensen S, et al. Br J Pharmacol. 2024 Apr 11. doi: 10.1111/bph.16362.

IP2015 (IPED2015, Pudafensine, NS18313)

生物&药学活性

物理化学性质&存储条件

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IP2015 (IPED2015, Pudafensine, NS18313)

生物&药学活性

物理化学性质&存储条件

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