IP-DNQ | NQO1 inhibitor | Probechem Biochemicals

Chemical Structure : IP-DNQ

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IP-DNQ (Isopentyl-deoxynboquinone)

货号: PC-21350Not For Human Use, Lab Use Only.

IP-DNQ (Isopentyl-deoxynboquinone) is a small molecule that selectively kills pancreatic ductal adenocarcinoma cells in an NQO1-dependent manner.

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1 g		Get quote

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生物&药学活性

IP-DNQ (Isopentyl-deoxynboquinone) is a small molecule that selectively kills pancreatic ductal adenocarcinoma cells in an NQO1-dependent manner.
IP-DNQ evokes massive ROS production and oxidative DNA lesions that results in PARP1 hyperactivation, mitochondrial catastrophe and G2/M-phase arrest, leading to apoptotic and necrotic programmed cell death.
IP-DNQ treatment causes mild methemoglobinemia in vivo, with a three-fold improvement in the maximum tolerated dose compared to DNQ, while significantly suppresses tumor growth and extends the lifespan of mice in subcutaneous and orthotopic pancreatic cancer xenograft models.

物理化学性质&存储条件

分子量	340.38
分子式	C19H20N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-isopentyl-4,6-dimethylpyrido[3,2-g]quinoline-2,5,8,10(1H,9H)-tetraone

参考文献

1. Lingxiang Jiang, et al. Antioxid Redox Signal. 2023 Nov 11. doi: 10.1089/ars.2022.0224.

IP-DNQ (Isopentyl-deoxynboquinone)

生物&药学活性

物理化学性质&存储条件

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IP-DNQ (Isopentyl-deoxynboquinone)

生物&药学活性

物理化学性质&存储条件

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