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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-IOX4
IOX4

Chemical Structure : IOX4

CAS No.: 1154097-71-8

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IOX4 (PHD2 inhibitor IOX4)

货号: PC-35269Not For Human Use, Lab Use Only.

IOX4 (PHD2 inhibitor IOX4) is a potent, selective inhibitor of prolyl hydroxylase domain enzyme PHD2 with IC50 of 1.6 nM, displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases.

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10 mg ￥980 In stock
25 mg ￥1480 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IOX4 (PHD2 inhibitor IOX4) is a potent, selective inhibitor of prolyl hydroxylase domain enzyme PHD2 with IC50 of 1.6 nM, displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases.
IOX4 inhibits prolyl hydroxylation and increases HIF-1α levels in cells (IC50=5.6 to 11.7 µM), also induces HIF-1α and HIF-2α expression in mice.

物理化学性质&存储条件

分子量 328.3
分子式 C15H16N6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,1-dimethylethyl ester 6-[2,5-dihydro-5-oxo-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl]-3-pyridinecarboxylic acid

参考文献

1. Chan MC, et al. PLoS One. 2015 Jul 6;10(7):e0132004.

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