IOI-42 | hPEBP4 inhibitor | Probechem Biochemicals

Chemical Structure : IOI-42

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IOI-42 (hPEBP4 inhibitor IOI-42)

货号: PC-20703Not For Human Use, Lab Use Only.

hPEBP4 inhibitor IOI-42 is a small molecule inhibitor of anti-apoptotic protein hPEBP4, potentiates TNF-α-mediated growth inhibition of MCF-7 breast cancer cells.

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生物&药学活性

hPEBP4 inhibitor IOI-42 is a small molecule inhibitor of anti-apoptotic protein hPEBP4, potentiates TNF-α-mediated growth inhibition of MCF-7 breast cancer cells.
IOI-42 promotes TRAIL-induced apoptosis of human prostate cancer cells.
IOI-42 (10 μM) enhances the inhibitory effect of TNF-α (20 ng/ml) on anchorage-independent growth of MCF-7 human breast cancer cells.
IOI-42 could impair the association of hPEBP4 with Raf-1 and MEK1 specifically and potentially and therefore block the suppressive effect of hPEBP4 on the TNF-α-induced activation of Raf-1/MEK1/ERK cascade.
IOI-42 is the first chemical inhibitor of hPEBP4, interacts with hPEBP4 in vitro, potentiates TNF-α/TRAIL-induced tumor cell apoptosis.

物理化学性质&存储条件

分子量	427.48
分子式	C24H17N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)C1=CC=C(NC(NC(C2=CC(C3=CC=CC=C3)=NC4=CC=CC=C24)=O)=S)C=C1

参考文献

1. Qiu J, et al. J Biol Chem. 2010 Apr 16;285(16):12241-7.

IOI-42 (hPEBP4 inhibitor IOI-42)

生物&药学活性

物理化学性质&存储条件

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IOI-42 (hPEBP4 inhibitor IOI-42)

生物&药学活性

物理化学性质&存储条件

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