IOI-214 | | Probechem Biochemicals

Chemical Structure : IOI-214

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IOI-214 (IOI 214)

货号: PC-21466Not For Human Use, Lab Use Only.

IOI-214 is a potent inhibitor of LPS-induced inflammatory cytokine production, prevent HF diet-induced NAFLD/MAFLD in vivo.

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生物&药学活性

IOI-214 is a potent inhibitor of LPS-induced inflammatory cytokine production, prevent HF diet-induced NAFLD/MAFLD in vivo.
IOI-214 prevents LPS-induced inflammation in murine macrophages and hepatocytes in culture.
IOI-214 potently attenuates the robust LPS-induced upregulation of proinflammatory cytokine gene expression (Tnf, Ifnb1, Ccl2, Il1b, and Il6) in the cultured murine macrophages.
IOI-214 blocks HF diet-induced mesenteric fat accumulation without affecting HF diet-induced weight gain or subcutaneous fat accumulation.
IOI-214 (1 mg/kg, i.p.) ameliorates HF diet-induced hepatic steatosis.
IOI-214 mitigates HF diet-induced fasting hyperglycemia, without affecting fasting serum insulin, cholesterol or triglyceride levels, or glucose intolerance.
IOI-214 blocks HF diet-induced hepatic inflammatory cytokine and chemokine protein levels in vivo.

物理化学性质&存储条件

分子量	235.36
分子式	C12H13NS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-phenyl-3-propylthiazole-2(3H)-thione

参考文献

1. Kelly D McCall, et al. J Inflamm Res. 2023 Nov 16:16:5339-5366.

IOI-214 (IOI 214)

生物&药学活性

物理化学性质&存储条件

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IOI-214 (IOI 214)

生物&药学活性

物理化学性质&存储条件

参考文献

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