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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-IODVA1
IODVA1

Chemical Structure : IODVA1

CAS No.: 2531161-61-0

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IODVA1 (IODVA 1)

货号: PC-38152Not For Human Use, Lab Use Only.

IODVA1 is a small molecule with cellular inhibitory activity against several transformed cell lines including Ras-driven cells, targets Rac activation and signaling instead of Ras.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    IODVA1 is a small molecule with cellular inhibitory activity against several transformed cell lines including Ras-driven cells, targets Rac activation and signaling instead of Ras.
    IODVA1 inhibits ST8814 cell proliferation with GI50 of 1 uM, similar results were observed with MCF7, MDA-MB-231, and T47D cells with estimated GI50s <1 uM.
    IODVA1 significantly decreases number of colonies of the breast cancer cells in soft agar at 1 and 3 uM.
    IODVA1 probably does not bind Ras and that its mechanism of action is likely Ras-independent, inhibits lamellipodia and circular dorsal ruffle (CDR) formation in MDA-MB-231 cells and decreases Rac activation.
    IODVA1 inhibits Rac activation and downstream signaling leading to inhibition of lamellipodia and CDR formation.
    IODVA1 inhibits cell-substratum and cell-cell interactions, does not target kinases, and reduces tumor burden of solid tumors in vivo.

    物理化学性质&存储条件

    分子量 369.388
    分子式 C20H15N7O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-2-((1H-benzo[d]imidazol-2-yl)imino)-4,5-di(pyridin-2-yl)-2,5-dihydro-1H-imidazol-5-ol

    参考文献

    1. Gasilina A, et al. PLoS One. 2020 Mar 12;15(3):e0229801.

    2. Hegde S, et al. Leukemia. 2021 Oct 28. doi: 10.1038/s41375-021-01455-3.

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