INU-101 | 11β-HSD1 inhibitor | Probechem Biochemicals

Chemical Structure : INU-101

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INU-101 (INU101, INU 101)

货号: PC-35573Not For Human Use, Lab Use Only.

INU-101 (INU101) is a highly potent, selective, orally acitve 11β-HSD1 inhibitor with IC50 of 26.2 nM, 37 nM and 0.6 nM for mice, rat, and human 11β-HSD1, respectively.

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生物&药学活性

INU-101 (INU101) is a highly potent, selective, orally acitve 11β-HSD1 inhibitor with IC50 of 26.2 nM, 37 nM and 0.6 nM for mice, rat, and human 11β-HSD1, respectively.
INU-101 displays good selectivity for human 11β-HSD1 over 11β-HSD2 (IC50>10 uM).
INU-101 significantly inhibits the 11β-HSD1 activity in mice 3T3-L1 adipocytes (IC50=9.1 nM), enhances insulin sensitivity and lowers the fasting blood glucose level in KKAy mice, ob/ob mice and ZDF rats after oral administration, decreases the body weight and ameliorates an improved lipid profile in the diabetic mouse model.

物理化学性质&存储条件

分子量	437.53
分子式	C21H28FN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,3R,4S,5S,7S)-4-(2-((2-fluorophenyl)sulfonamido)-2-methylpropanamido)adamantane-1-carboxamide

参考文献

1. Hong SP, et al. Eur J Pharmacol. 2018 Aug 7. pii: S0014-2999(18)30450-3.

INU-101 (INU101, INU 101)

生物&药学活性

物理化学性质&存储条件

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INU-101 (INU101, INU 101)

生物&药学活性

物理化学性质&存储条件

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