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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Farnesoid X Receptor (FXR)-INT-747
INT-747

Chemical Structure : INT-747

CAS No.: 459789-99-2

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INT-747 (Obeticholic acid;6-ECDCA;6-Ethylchenodeoxycholic acid;INT747)

货号: PC-42924Not For Human Use, Lab Use Only.

INT-747 (Obeticholic acid, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective FXR agonist (EC50=99 nM).

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10 mg ￥680 In stock
25 mg ￥1180 In stock
50 mg ￥1880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

INT-747 (Obeticholic acid, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective FXR agonist (EC50=99 nM).
INT-747 possesses anticholeretic activity in rat model of cholestasis.

物理化学性质&存储条件

分子量 420.6252
分子式 C26H44O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 33 mg/mL
Chemical Name/SMILES

Cholan-24-oic acid, 6-ethyl-3,7-dihydroxy-, (3α,5β,6α,7α)-

参考文献

1. Pellicciari R, et al. J Med Chem. 2002 Aug 15;45(17):3569-72.

2. Fiorucci S, et al. J Pharmacol Exp Ther. 2005 May;313(2):604-12.

3. Rizzo G, et al. Mol Pharmacol. 2006 Oct;70(4):1164-73.

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