INR119 | MEK1/2 inhibitor | Probechem Biochemicals

Chemical Structure : INR119

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INR119 (INR-119)

货号: PC-73276Not For Human Use, Lab Use Only.

INR119 is a small molecule allosteric MAPKK (MAP2K, MEK1/2) inhibitor, binds fission yeast homologue Wis1 near C458 and protects Wis1 from inactivation by low levels of H2O2 in vitro.

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生物&药学活性

INR119 is a small molecule allosteric MAPKK (MAP2K, MEK1/2) inhibitor, binds fission yeast homologue Wis1 near C458 and protects Wis1 from inactivation by low levels of H2O2 in vitro.
INR119 pretreatment strongly potentiates the Wis1 response to low H2O2 in vivo.
Phosphorylation of Sty1 depends entirely on activated Wis1, and the INR119-induced enhancement of Sty1 pathway activation upon H2O2 stress requires the upstream activation of Wis1 through the MAPKKKs.

物理化学性质&存储条件

分子量	281.311
分子式	C17H15NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-amino-3-ethoxyphenyl)-4H-chromen-4-one

参考文献

1. Sjölander JJ, et al. Mol Cell Biol. 2020 Mar 16;40(7):e00346-19.

2. Redwan IN, et al. Eur J Med Chem 85:127–138.

3. Otręba M, et al. Life (Basel). 2021 Mar 31;11(4):297.

INR119 (INR-119)

生物&药学活性

物理化学性质&存储条件

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INR119 (INR-119)

生物&药学活性

物理化学性质&存储条件

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