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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-INP0010
INP0010

Chemical Structure : INP0010

CAS No.: 1255240-00-6

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INP0010 (INP-0010)

货号: PC-27562Not For Human Use, Lab Use Only.

INP0010 is a small-molecular inhibitor of bacterial virulence factor, inhibits type III secretion system (T3SS), prevents virulence factor-mediated replication of S. Typhimurium in macrophage-like RAW264.7 cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

INP0010 is a small-molecular inhibitor of bacterial virulence factor, inhibits type III secretion system (T3SS), prevents virulence factor-mediated replication of S. Typhimurium in macrophage-like RAW264.7 cells.
INP0010 enhances expression of inducible nitric oxide synthase (iNOS), nitric oxide (NO) production, the oxidative burst and tumour necrosis factor-alpha (TNFα) release in infected RAW264.7 cells.
INP0010 also inhibits virulence-associated Salmonella pathogenicity island 2 (SPI2) activity in RAW264.7 cells.
INP0010 significantly attenuates the virulence of S. Typhimurium in Caenorhabditis elegans.

物理化学性质&存储条件

分子量 399.04
分子式 C13H9Br2N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N'-(3,5-dibromo-2-hydroxybenzylidene)nicotinohydrazide

参考文献

1. Gu L, et al. Molecules (Basel, Switzerland) 2015;20(9):17659–17674.

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