INI-60 | Kpnβ1 inhibitor | Probechem Biochemicals

Chemical Structure : INI-60

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INI-60 (Inhibitor of Nuclear Import-60)

货号: PC-72017Not For Human Use, Lab Use Only.

INI-60 (Inhibitor of Nuclear Import-60) is a novel small molecule inhibitor of Kpnβ1-mediated nuclear import with anti-cancer activity.

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生物&药学活性

INI-60 (Inhibitor of Nuclear Import-60) is a novel small molecule inhibitor of Kpnβ1-mediated nuclear import with anti-cancer activity.
INI-60 treatment resulted in the inhibition of cancer cell proliferation, colony formation, migration and invasion, and induced a G1/S cell cycle arrest, followed by cancer cell death via apoptosis.
INI-60 treatment altered the localisation of Kpnβ1 and its cargoes, NFκB/p65, NFAT and AP-1, and the overexpression of Kpnβ1 reduced INI-60 cytotoxicity.
INI-60 also inhibited KYSE 30 oesophageal cancer cell line growth in vivo.

物理化学性质&存储条件

分子量	477.667
分子式	C28H35N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-((1-methylpiperidin-3-yl)methoxy)-4-((6-methylpyridin-2-yl)methyl)-7-(5-methylthiophen-2-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine

参考文献

1. Ajayi-Smith A, et al. Exp Cell Res. 2021 Jul 15;404(2):112637.

INI-60 (Inhibitor of Nuclear Import-60)

生物&药学活性

物理化学性质&存储条件

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INI-60 (Inhibitor of Nuclear Import-60)

生物&药学活性

物理化学性质&存储条件

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