INI-43 | Kpnβ1 inhibitor | Probechem Biochemicals

Chemical Structure : INI-43

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INI-43 (Inhibitor of Nuclear Import-43, ZINC20547783)

货号: PC-72015Not For Human Use, Lab Use Only.

INI-43 (Inhibitor of Nuclear Import-43, ZINC20547783) is a small molecule that bind nuclear import receptor Karyopherin beta 1 (Kpnβ1), inhibits Kpnβ1-mediated nuclear import with anti-cancer activity.

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生物&药学活性

INI-43 (Inhibitor of Nuclear Import-43, ZINC20547783) is a small molecule that bind nuclear import receptor Karyopherin beta 1 (Kpnβ1), inhibits Kpnβ1-mediated nuclear import with anti-cancer activity.
INI-43 significantly diminished NFAT activation in a dosedependent manner (IC50=9.3 uM in HeLa cells).
INI-43 prevents transcription factor and Kpnβ1 access to the nucleus, and INI-43 treatment results in cancer cell death via a G2/M cell cycle arrest.
INI-43 treatment induces cancer cell cycle changes and apoptosis and inhibits tumour growth in vivo.

物理化学性质&存储条件

分子量	385.475
分子式	C22H23N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1H-benzimidazol-2-yl)-1-[3-(dimethylamino)propyl]pyrrolo[3,2-b]quinoxalin-2-amine

参考文献

1. Pauline J van der Watt, et al. Mol Cancer Ther. 2016 Apr;15(4):560-73.

INI-43 (Inhibitor of Nuclear Import-43, ZINC20547783)

生物&药学活性

物理化学性质&存储条件

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INI-43 (Inhibitor of Nuclear Import-43, ZINC20547783)

生物&药学活性

物理化学性质&存储条件

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