INH154 |CAS:1587705-63-2 Probechem Biochemicals

Chemical Structure : INH154

CAS No.: 1587705-63-2

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INH154 (INH 154, INH-154)

货号: PC-61480Not For Human Use, Lab Use Only.

INH154 is a novel small molecules disrupting Hec1/Nek2 interaction, inhibits HeLa and MDA-MB-468 cancer cells growth with IC50 of 0.20 and 0.12 uM, respectively.

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10 mg	￥2480	In stock
25 mg	￥3980	In stock
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生物&药学活性

INH154 is a novel small molecules disrupting Hec1/Nek2 interaction, inhibits HeLa and MDA-MB-468 cancer cells growth with IC50 of 0.20 and 0.12 uM, respectively.
INH154 suppresses the growth of leukemia, osteosarcoma, and glioblastoma cells, but has no significant growth inhibitory effects on non-tumorigenic fibroblast, HS27 and mammary epithelial cells.
INH-154 triggers Nek2 degradation and eventually cell death, suppresses tumor growth in mice without obvious toxicity.

物理化学性质&存储条件

分子量	392.521
分子式	C22H24N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2,6-dimethyl-4-(piperidin-1-yl)phenyl)thiazol-2-yl)isonicotinamide

参考文献

1. Hu CM, et al. Oncogene. 2015 Mar 5;34(10):1220-30.

INH154 (INH 154, INH-154)

生物&药学活性

物理化学性质&存储条件

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INH154 (INH 154, INH-154)

生物&药学活性

物理化学性质&存储条件

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