INH-12 | HSD17B12 inhibitor | Probechem Biochemicals

Chemical Structure : INH-12

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INH-12 (HSD17B12 inhibitor INH-12)

货号: PC-72079Not For Human Use, Lab Use Only.

INH-12 is a selective small-molecule HSD17B12 inhibitor with 70% inhibition of HSD17B12 activity to transform estrone (E1) into estradiol (E2) at 1 uM, reduces the replication of Flaviviridae viruses (HCV, DENV and ZIKV).

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生物&药学活性

INH-12 is a selective small-molecule HSD17B12 inhibitor with 70% inhibition of HSD17B12 activity to transform estrone (E1) into estradiol (E2) at 1 uM, reduces the replication of Flaviviridae viruses (HCV, DENV and ZIKV).
INH-12 shows no inhibitory activity against the C19 steroid metabolizing enzyme HSD17B3.
INH-12 dose-dependently inhibits DENV and ZIKV with mean EC50 values of 5.3 µM and 14.6 µM, respectively.
INH-12 shows potential of HSD17B12 inhibition as an antiviral target with a pan-Flaviviridae spectrum.

物理化学性质&存储条件

分子量	417.593
分子式	C28H35NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((13S,17R)-17-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)methyl)-N,N-dimethylbenzamide

参考文献

1. Siham Farhane, et al. Med Chem. 2011 Mar;7(2):80-91.

2. Bassim Mohamed, et al. Sci Rep. 2020 Mar 4;10(1):4040.

INH-12 (HSD17B12 inhibitor INH-12)

生物&药学活性

物理化学性质&存储条件

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INH-12 (HSD17B12 inhibitor INH-12)

生物&药学活性

物理化学性质&存储条件

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