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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Influenza Virus-ING-1466
ING-1466

Chemical Structure : ING-1466

CAS No.: 2739990-96-4

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ING-1466 (ING1466, ING14-66)

货号: PC-21830Not For Human Use, Lab Use Only.

ING-1466 is an orally active entry inhibitor of influenza A viruses (IAVs) with EC50 of 0.18 uM against IAV H1N1 (PR8-NS1-Gluc), binds to hemagglutinin (HA) and blocks HA-mediated viral infection.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ING-1466 is an orally active entry inhibitor of influenza A viruses (IAVs) with EC50 of 0.18 uM against IAV H1N1 (PR8-NS1-Gluc), binds to hemagglutinin (HA) and blocks HA-mediated viral infection.
    ING-1466 has an EC50 value of 0.013 μM against pdm2009 H1N1 (A/Brownsville/39H/2009), but ING-1466 is less effective against a tissue culture adapted H1N1 PR8 virus (EC50, 3.10 μM) that has a V115M mutation in the HA2 (ATCC VR-1469).
    ING-1466 shows no cytotoxicity at 100 uM in both A549 and HepG2 cells.
    ING-1466 (25 and 50 mg/kg per day, i.p. or oral) produces strong inhibitory effect on infection in H1N1 mouse model.
    ING-1466 alone or in combination with other drugs protects mice from IAV lethal infection.
    ING-1466 has activity not only against influenza virus H1N1 (A/Puerto Rico/8/1934) but also against H5N1 (A/Vietnam/1203/2004) and the oseltamivir-resistant strains carrying NA/H274Y mutations.

    物理化学性质&存储条件

    分子量 362.82
    分子式 C17H22ClF3N2O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(1-(tert-butyl)piperidin-4-yl)-2-chloro-4-(trifluoromethyl)benzamide

    参考文献

    1. Gaisina I, et al. Sci Adv. 2024 Feb 23;10(8):eadk9004.

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