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首页-小分子抑制剂&激动剂-Tyrosine Kinase-DYRK-INDY
INDY

Chemical Structure : INDY

CAS No.: 1169755-45-6

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INDY (Inhibitor of Dyrk)

货号: PC-22436Not For Human Use, Lab Use Only.

INDY is a potent, selective and ATP-competitive inhibitor of Dyrk1A withIC50 and Ki values of 0.24 and 0.18 μM, respectively.

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5 mg ￥680 In stock
10 mg ￥980 In stock
25 mg ￥1680 In stock
50 mg ￥2680 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

INDY is a potent, selective and ATP-competitive inhibitor of Dyrk1A withIC50 and Ki values of 0.24 and 0.18 μM, respectively.
INDY also inhibited Dyrk1B, the closest Dyrk kinase family member to Dyrk1A, with an IC50 of 0.23 μM.
INDY (10 μM) shows >90% inhibition on DYRK2, DYRK3 and four other kinases, namely CLK1, CLK4, casein kinase 1 (CSNK1D) and PIM1.
INDY effectively reversed the aberrant tau-phosphorylation and rescued the repressed NFAT (nuclear factor of activated T cell) signalling induced by Dyrk1A overexpression.
INDY is capable of manipulating the activity levels of the kinase in cultured cells and Xenopus embryos.
INDY is a valuable tool for the research of Dyrk1A-related diseases including DS, and may lead to invention of a novel therapeutic strategy for the diseases.

物理化学性质&存储条件

分子量 235.30
分子式 C12H13NO2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-1-(3-Ethyl-5-hydroxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one

参考文献

1. Masaki S, et al. Bioorg Med Chem. 2015 Aug 1;23(15):4434-4441.

2. Ogawa Y, et al. Nat Commun. 2010 Oct 5;1:86.

3. MacDonald J, et al. Mol Cancer Res. 2017 Apr;15(4):371-381.

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