INCB126503 | FGFR2/3 inhibitor | Probechem Biochemicals

Chemical Structure : INCB126503

加入收藏

INCB126503 (INCB-126503)

货号: PC-24894Not For Human Use, Lab Use Only.

INCB126503 is a highly potent, selective, orally bioavailable FGFR2/3 inhibitor with IC50 of 2.1/1.2 nM respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

INCB126503 is a highly potent, selective, orally bioavailable FGFR2/3 inhibitor with IC50 of 2.1/1.2 nM respectively.
INCB126503 shows potent activity when tested against both of the FGFR3 gatekeeper mutants FGFR3-V555L (IC50 = 0.92 nM) and FGFR3-V555 M (IC50 = 0.85 nM).
INCB126503 displays single-digit nanomolar potency against FGFR3 in BAF3 cells (IC50 = 6.8 nM) while featuring excellent selectivity over FGFR1 (58-fold), also is highly selective over FGFR4 (IC50 = 64 nM).
INCB126503 inhibits both pFGFR3 and pERK signaling in RT112/84 tumor cells following a single oral dose of 100 mg/kg in RT112/84 tumors, demonstrates significant antitumor efficacy without inducing hyperphosphatemia.

物理化学性质&存储条件

分子量	470.58
分子式	C27H30N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrrolo[1,2-a]pyrazin-7-ol, 2-[5-[5-(2,3-dimethylphenyl)-6-methoxy-1H-pyrazolo[4,3-b]pyridin-3-yl]-2-pyridinyl]octahydro-, (7R,8aS)-

参考文献

1. Nguyen MH, et al. ACS Med Chem Lett. 2025 May 17;16(6):1182-1189.

INCB126503 (INCB-126503)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

INCB126503 (INCB-126503)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.