INCB057643 |CAS:1820889-23-3 Probechem Biochemicals

Chemical Structure : INCB057643

CAS No.: 1820889-23-3

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INCB057643 (INCB 057643)

货号: PC-63272Not For Human Use, Lab Use Only.

INCB057643 is a novel potent, selective, orally bioavailable BET inhibitor, reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

INCB057643 is a novel potent, selective, orally bioavailable BET inhibitor, reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer.
INCB057643 shows more effectivity against androgen-dependent (VCaP and LNCaP) than androgen-independent (DU145 and PC3) cells with IC50 of <100 nM and >500 nM, respectively.
INCB057643 significantly causes inhibition of tumor growth in mice bearing 22Rv1 tumor xenografts.

物理化学性质&存储条件

分子量	415.464
分子式	C20H21N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

参考文献

1. Wilson AJ, et al. Gynecol Oncol. 2018 Mar 20. pii: S0090-8258(18)30229-4.

INCB057643 (INCB 057643)

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物理化学性质&存储条件

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INCB057643 (INCB 057643)

生物&药学活性

物理化学性质&存储条件

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