INCA-6 | NFAT inhibitor | Probechem Biochemicals

Chemical Structure : INCA-6

CAS No.: 3519-82-2

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INCA-6 (Inhibitor of NFAT-calcineurin association 6)

货号: PC-26146Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

INCA-6 (Inhibitor of NFAT-calcineurin association 6) is a specific, cell-permeable nuclear factor of activated T cells (NFAT) inhibitor, binds to calcineurin with high affinity (KD=0.8 uM) and specifically disrupts its interaction with NFAT.
INCA-6 (20 μM and 40 μM) inhibits activation of NFAT in Cl.7W2 T cells.
INCA-6 inhibits NFAT dephosphorylation and nuclear export in T cells.
INCA-6 (20 μM and 40 μM) inhibits the induction of NFAT-dependent cytokine mRNAs in Cl.7W2 T cells.

物理化学性质&存储条件

分子量	284.31
分子式	C20H12O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9,10-Dihydro-9,10[1,2]-benzenoanthracene-1,4-dione

参考文献

1. Xiao L, et al. Circ Res. 2008 Sep 26;103(7):733-42.

2. Michael H A Roehrl, et al. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7554-9.

3. Shiratori M, et al. J Neurochem. 2010 Aug;114(3):810-9.

4. Jabr RI, et al. Am J Physiol Cell Physiol. 2007 Jun;292(6):C2213-25.

INCA-6 (Inhibitor of NFAT-calcineurin association 6)

生物&药学活性

物理化学性质&存储条件

参考文献

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INCA-6 (Inhibitor of NFAT-calcineurin association 6)

生物&药学活性

物理化学性质&存储条件

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