Izumerogant (IMU-935) | RORγt antagonist | Probechem Biochemicals

Chemical Structure : IMU-935

加入收藏

IMU-935 (Izumerogant, IMU935, IM105935)

货号: PC-20040Not For Human Use, Lab Use Only.

IMU-935 (Izumerogant, IMU935, IM105935) is a potent, selective and orally available inverse agonist of retinoic acid-related orphan receptor gamma (RORγt) with IC50 of 24 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

IMU-935 (Izumerogant, IMU935, IM105935) is a potent, selective and orally available inverse agonist of retinoic acid-related orphan receptor gamma (RORγt) with IC50 of 24 nM.
IMU-935 is shown to be a DHODH Inhibitor with an IC50 of 240 nM.
IMU-935 demonstrates synergistic inhibition of the secretion of IL-17A, IL-17F and IFNγ with IC50 concentrations of 3-5 nM tested in stimulated human lymphocytes.
IMU-935 inhibits Th17 differentiation of murine cells (IC50=135 nM), and inhibits IL-17F production from stimulated human PBMCs with IC50 of 2-4 nM.
IMU-935 demonstrates a strong inhibition of GM-CSF, IL-17A, IL-17F and IL-22 in inflamed human skin model (skin punches from human healthy volunteers).
IMU-935 does not affect thymocyte development.

物理化学性质&存储条件

分子量	495.86
分子式	C22H18ClF4N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(3-(2-chloro-6-fluorophenyl)-4-(pyrimidin-2-yl)isoxazol-5-yl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-2-methylbutan-2-ol

参考文献

1. Patent WO2019048541. 2019-03-14.

IMU-935 (Izumerogant, IMU935, IM105935)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

IMU-935 (Izumerogant, IMU935, IM105935)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.