IMTPPE | AR inhibitor | Probechem Biochemicals

Chemical Structure : IMTPPE

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IMTPPE (SID 3712502)

货号: PC-35866Not For Human Use, Lab Use Only.

IMTPPE (SID 3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells.

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生物&药学活性

IMTPPE (SID 3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells.
IMTPPE inhibited proliferation of AR-positive, but not AR-negative, prostate cancer cells in culture.
IMTPPE inhibited the transcriptional activity of a mutant AR lacking the ligand-binding domain (LBD).
IMTPPE inhibited the growth of 22Rv1 xenograft tumor, a model for enzalutamide-resistant prostate cancer.

物理化学性质&存储条件

分子量	373.52
分子式	C20H27N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(((3,5-dimethylisoxazol-4-yl)methyl)thio)-1-(4-(2,3-dimethylphenyl)piperazin-1-yl)ethan-1-one

参考文献

1. Masoodi KZ, et al. Endocrinology. 2017 Oct 1;158(10):3152-3161.

IMTPPE (SID 3712502)

生物&药学活性

物理化学性质&存储条件

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IMTPPE (SID 3712502)

生物&药学活性

物理化学性质&存储条件

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