IMT1B (LDC203974)

Chemical Structure : IMT1B

CAS No.: 2304621-06-3

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货号: PC-72917Not For Human Use, Lab Use Only.

IMT1B (LDC203974) is a first-in-class specific inhibitor of mitochondrial transcription that target the human mitochondrial RNA polymerase (POLRMT).

规格	价格	库存
5 mg	￥1780	In stock
10 mg	￥2580	In stock
25 mg	￥4580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

IMT1B (LDC203974) is a first-in-class specific inhibitor of mitochondrial transcription that target the human mitochondrial RNA polymerase (POLRMT).
IMT1B exhibits antiproliferative activity in A2780 cells with IC50 of 138 nM.
IMT1B is well-tolerated in mice, and suitable for in vivo use.
IMT1B does not cause OXPHOS dysfunction or toxicity in normal tissues, despite inducing a strong anti-tumour response in xenografts of human cancer cells.

物理化学性质&存储条件

分子量	473.88
分子式	C24H21ClFNO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO (4.74 mg/mL)
Chemical Name/SMILES	(S)-1-((R)-2-((4-(2-chloro-4-fluorophenyl)-2-oxo-2H-chromen-7-yl)oxy)propanoyl)piperidine-3-carboxylic acid

参考文献

1. Bonekamp NA, et al. Nature. 2020 Dec;588(7839):712-716.

IMT1B (LDC203974)

生物&药学活性

物理化学性质&存储条件

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IMT1B (LDC203974)

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