IMR-1A |CAS:331862-41-0 Probechem Biochemicals

Chemical Structure : IMR-1A

CAS No.: 331862-41-0

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IMR-1A (IMR1A;IMR 1A)

货号: PC-42155Not For Human Use, Lab Use Only.

IMR-1A is a small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=0.5 uM).

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
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生物&药学活性

IMR-1A is a small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=0.5 uM).
IMR-1A non-covalently binds to intracellular domain of Notch (NICD) with Kd of 2.9 uM.
IMR-1A inhibits Notch target gene transcription and selectively suppresses colony formation of Notch-dependent cell lines.
IMR-1A is the acid metabolite of IMR-1.

物理化学性质&存储条件

分子量	325.3601
分子式	C13H11NO5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-

参考文献

1. Astudillo L, et al. Cancer Res. 2016 Jun 15;76(12):3593-603.

IMR-1A (IMR1A;IMR 1A)

生物&药学活性

物理化学性质&存储条件

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IMR-1A (IMR1A;IMR 1A)

生物&药学活性

物理化学性质&存储条件

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