IMR-1 |CAS:310456-65-6 Probechem Biochemicals

Chemical Structure : IMR-1

CAS No.: 310456-65-6

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IMR-1 (IMR1;IMR 1)

货号: PC-42154Not For Human Use, Lab Use Only.

A small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=26 uM).

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

IMR-1 is a small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=26 uM).
IMR-1 non-covalently binds to intracellular domain of Notch (NICD) with Kd of 11 uM, inhibits Notch target gene transcription and selectively suppresses colony formation of Notch-dependent cell lines。
IMR-1 dramatically inhibits tumor growth in a patient-derived tumor xenograft model.

物理化学性质&存储条件

分子量	353.4133
分子式	C15H15NO5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-, ethyl ester

参考文献

1. Astudillo L, et al. Cancer Res. 2016 Jun 15;76(12):3593-603.

IMR-1 (IMR1;IMR 1)

生物&药学活性

物理化学性质&存储条件

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IMR-1 (IMR1;IMR 1)

生物&药学活性

物理化学性质&存储条件

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