IMP-1700 | Bacterial AddAB complex inhibitor | Probechem Biochemicals

Chemical Structure : IMP-1700

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IMP-1700 (IMP 1700)

货号: PC-20571Not For Human Use, Lab Use Only.

IMP-1700 (IMP1700) is a potent, cell-active inhibitor of bacterial AddAB-mediated DNA repair, sensitizes MRSA to ciprofloxacin (CFX) with an EC50 of 5.9 nM.

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生物&药学活性

IMP-1700 (IMP1700) is a potent, cell-active inhibitor of bacterial AddAB-mediated DNA repair, sensitizes MRSA to ciprofloxacin (CFX) with an EC50 of 5.9 nM.
IMP-1700 is a high potency potentiator of DNA damage in bacterial cells.
IMP-1700 inhibits the bacterial SOS-response to DNA damage.
IMP-1700 demonstrates potential as a combinational therapy to combat serious drug-resistant infections.
IMP-1700 is a small molecule inhibitor of the AddAB/RecBCD DNA repair complexes.

物理化学性质&存储条件

分子量	534.53
分子式	C25H22F4N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CCN(C(NC5=CC=C(C(F)(F)F)C=C5)=S)CC4)=C3)C1=O)O

参考文献

1. Carine S Q Lim, et al. Bioorg Med Chem. 2019 Oct 15;27(20):114962.

IMP-1700 (IMP 1700)

生物&药学活性

物理化学性质&存储条件

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IMP-1700 (IMP 1700)

生物&药学活性

物理化学性质&存储条件

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