IMP-1575 | HHAT inhibitor | Probechem Biochemicals

Chemical Structure : IMP-1575

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IMP-1575 (IMP1575, IMP 1575)

货号: PC-72790Not For Human Use, Lab Use Only.

IMP-1575 (IMP1575) is a potent, selective Hedgehog acyltransferase (HHAT) inhibitor with Ki/IC50 of 38 nM/0.75 uM (Acyl-cLIP assay).

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生物&药学活性

IMP-1575 (IMP1575) is a potent, selective Hedgehog acyltransferase (HHAT) inhibitor with Ki/IC50 of 38 nM/0.75 uM (Acyl-cLIP assay).
IMP-1575 is the first sub-micromolar small-molecule HHAT inhibitor reported to-date.
IMP‐1575 (50-0.023 μM) was therefore analyzed for effects on HHAT kinetics at varying Pal‐CoA concentrations (50–0.19 μM).
IMP-1575 is a chemical tool and methodology to provide insight into HHAT which may expedite future studies and drug discovery efforts against this important target class.

物理化学性质&存储条件

分子量	343.489
分子式	C19H25N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(isobutylamino)-1-(4-(6-methylpyridin-2-yl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethan-1-one

参考文献

1. Lanyon-Hogg T, et al. Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13542-13547.

2. Coupland CE, et al. Mol Cell. 2021 Dec 16;81(24):5025-5038.e10.

IMP-1575 (IMP1575, IMP 1575)

生物&药学活性

物理化学性质&存储条件

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IMP-1575 (IMP1575, IMP 1575)

生物&药学活性

物理化学性质&存储条件

参考文献

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