IMP-1088 | N-myristoyltransferase inhibitor | Probechem Biochemicals

Chemical Structure : IMP-1088

CAS No.: 2059148-82-0

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IMP-1088 (IMP1088, IMP 1088)

货号: PC-63579Not For Human Use, Lab Use Only.

IMP-1088 is a potent, selective human N-myristoyltransferase with IC50 of less than 1 nM for both HsNMT1 and HsNMT2, inhibits Rhinoviruses (RVs) capsid myristoylation in cells.

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5 mg	￥2880	In stock
10 mg	￥4580	In stock
25 mg	￥7580	In stock
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生物&药学活性

IMP-1088 is a potent, selective human N-myristoyltransferase with IC50 of less than 1 nM for both HsNMT1 and HsNMT2, inhibits Rhinoviruses (RVs) capsid myristoylation in cells.
IMP-1088 pharmacological and rapidly inhibits host-cell N-myristoylation, potently and efficiently block RV replication (IC50=17 nM) without cytotoxicity.
IMP-1088 potently blocks a key step in viral capsid assembly, to deliver a low nanomolar antiviral activity against multiple RV strains, poliovirus and foot and-mouth disease virus, and protection of cells against virus-induced killing.

物理化学性质&存储条件

分子量	453.538
分子式	C25H29F2N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-(3,4-difluoro-2-(2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy)phenyl)-1-methyl-1H-indazol-3-yl)-N,N-dimethylmethanamine

参考文献

1. Aurélie Mousnier, et al. Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus. Nature Chemistry (2018). doi:10.1038/s41557-018-0039-2.

IMP-1088 (IMP1088, IMP 1088)

生物&药学活性

物理化学性质&存储条件

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IMP-1088 (IMP1088, IMP 1088)

生物&药学活性

物理化学性质&存储条件

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