IMMH-010 maleate (YPD-30) | PD-L1 inhibitor | Probechem Biochemicals

Chemical Structure : IMMH-010 maleate

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IMMH-010 maleate (IMMH010 maleate, YPD-30)

货号: PC-20280Not For Human Use, Lab Use Only.

IMMH-010 maleate (YPD-30) is an ester prodrug of YPD-29B, a high potent PD-L1 inhibitor (IC50=0.08 pM), YPD-30 is a potent PD-L1 inhibitor with IC50 of 45.2 nM in HTRF assays.

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100 mg		Get quote

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生物&药学活性

IMMH-010 maleate (YPD-30) is an ester prodrug of YPD-29B, a high potent PD-L1 inhibitor (IC50=0.08 pM), YPD-30 is a potent PD-L1 inhibitor with IC50 of 45.2 nM in HTRF assays.
YPD-30 is an orally bioavailable prodrug for YPD-29B with significantly higher bioavailability than YPD-29B.
YPD-30 exhibits antitumor activity by inhibiting PD-L1 in vivo, significantly increased T cell infiltration by increasing CD3 and CD8 expression in hPD-L1 MC38 xenograft tumor tissue, markedly decreased hPD-L1 expression.

物理化学性质&存储条件

分子量	756.04
分子式	C36H36BrClN2O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	isopropyl (4-((2-bromo-[1,1'-biphenyl]-3-yl)methoxy)-5-chloro-2-(pyridin-3-ylmethoxy)benzyl)-L-serinate maleate

参考文献

1. Fangfang Lai, et al. Acta Pharm Sin B. 2022 Jun;12(6):2845-2858.

2. Wang Y, et al. Pharmaceutics. 2021 Apr 21;13(5):598.

3. Patent: CN109153670.

IMMH-010 maleate (IMMH010 maleate, YPD-30)

生物&药学活性

物理化学性质&存储条件

参考文献

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IMMH-010 maleate (IMMH010 maleate, YPD-30)

生物&药学活性

物理化学性质&存储条件

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