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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-AMPK-IMM-H007
IMM-H007

Chemical Structure : IMM-H007

CAS No.: 1221412-23-2

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IMM-H007 (H007, WS070117)

货号: PC-38551Not For Human Use, Lab Use Only.

IMM-H007 (H007, WS070117) is a novel lipid-lowering agent and AMPK activator, reduces serum lipid levels and inhibits lipid accumulation both in vitro and in vivo.

规格 价格 库存 数量
5 mg ￥1480 In stock
10 mg ￥2380 In stock
25 mg ￥3980 In stock
50 mg ￥5980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IMM-H007 (H007, WS070117) is a novel lipid-lowering agent and AMPK activator, reduces serum lipid levels and inhibits lipid accumulation both in vitro and in vivo.
IMM-H007 (WS070117) (10 μM) inhibited cellular lipid accumulation induced by Oleic acid (0.25 mM).
IMM-H007 (WS070117) (0.1-10 uM) up-regulated AMPK signaling in OLA-induced steatosis in HepG2 cells, IMM-H007 (WS070117) (6 and 18 mg/kg) treatment also upregulated hepatic cellular AMPK phosphorylation in HFD fed hamsters.
IMM-H007 also activated AMPK and markedly suppressed AngII-induced TGF-β1 expression in human cardiac fibroblasts-adult ventricular, alleviated AngII-induced cardiac fibrosis by regulating AMPK-TGF-β1 signaling.

物理化学性质&存储条件

分子量 485.453
分子式 C22H23N5O8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2',3',5'-Tri-O-acetyl-N(6)-(3-hydroxyphenyl) adenosine

参考文献

1. Zhao Z, et al. Exp Biol Med (Maywood). 2012 Nov;237(11):1262-72.

2. Huang L, et al. J Lipid Res. 2015 May;56(5):986-97.

3. Shi H, et al. FEBS Open Bio. 2017 Aug 29;7(9):1379-1391.

4. Wang MJ, et al. Eur J Pharmacol. 2019 Jun 5;852:167-178.

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