IMM-02 (IMM02) | mDia-related formins agonist | Probechem Biochemicals

Chemical Structure : IMM-02

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IMM-02 (IMM 02)

货号: PC-62428Not For Human Use, Lab Use Only.

IMM-02 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 99 nM.

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生物&药学活性

IMM-02 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 99 nM.
IMM-02 sufficiently triggers actin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cycle arrest, and apoptosis in vitro.
IMM-02 slows tumor growth in a mouse xenograft model of colon cancer.

物理化学性质&存储条件

分子量	301.356
分子式	C13H17F2N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(tert-butyl)-2-[1-(3,5-difluoro-2-hydroxyphenyl)ethylidene]hydrazine-1-carbothioamide

参考文献

1. Lash LL, et al. Cancer Res. 2013 Nov 15;73(22):6793-803.

2. Arden JD, et al. Mol Biol Cell. 2015 Nov 1;26(21):3704-18.

IMM-02 (IMM 02)

生物&药学活性

物理化学性质&存储条件

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IMM-02 (IMM 02)

生物&药学活性

物理化学性质&存储条件

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