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首页-小分子抑制剂&激动剂-Others-Other Targets-IMM-01
IMM-01

Chemical Structure : IMM-01

CAS No.: 218795-74-5

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IMM-01 (IMM 01)

货号: PC-62427Not For Human Use, Lab Use Only.

IMM-01 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 140 nM.

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10 mg ￥2980 In stock
25 mg ￥4880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IMM-01 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 140 nM.
IMM-01 sufficiently triggers actin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cycle arrest, and apoptosis in vitro.
IMM-01 slows tumor growth in a mouse xenograft model of colon cancer.

物理化学性质&存储条件

分子量 267.347
分子式 C12H17N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N1-(tert-butyl)-2-(2,4-dihydroxybenzylidene)hydrazine-1-carbothioamide

参考文献

1. Lash LL, et al. Cancer Res. 2013 Nov 15;73(22):6793-803.

2. Arden JD, et al. Mol Biol Cell. 2015 Nov 1;26(21):3704-18.

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