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首页-小分子抑制剂&激动剂-NF-κB Pathway-IκB kinase (IKK)-IMD-0354
IMD-0354

Chemical Structure : IMD-0354

CAS No.: 978-62-1

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IMD-0354 (AER-270, IMD0354)

货号: PC-42418Not For Human Use, Lab Use Only.

IMD-0354 (AER-270) is a potent IκB kinase β (IKKbeta) inhibitor, also is a potent inhibitor of glutamine uptake.

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25 mg ￥780 In stock
50 mg ￥1180 In stock
100 mg ￥1880 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IMD-0354 (AER-270) is a potent IκB kinase β (IKKbeta) inhibitor, also is a potent inhibitor of glutamine uptake.
IMD-0354 ameliorated airway hyperresponsiveness and reduced the numbers of bronchial eosinophils and mucus-producing cells in OVA-sensitized mice.
IMD-0354 inhibits NF-κB activation and reduces the numbers of bronchial eosinophils.
IMD-0354 inhibitsIL-13 and IL-1β production, and it restored the production of IFN-γ.
IMD-0354 attenuatesmTOR signaling, suppressed two- and three-dimensional growth of melanoma cells, and induces cell-cycle arrest, autophagy, and apoptosis in melanoma.
IMD-0354 suppressed melanoma growth in a xenograft model.
IMD-0354 (AER-270) also is a selective, small molecule inhibitor of aquaporin-4 (AQP4) with IC50 of 0.24 uM, reduce AQP4-mediated water permeability.

物理化学性质&存储条件

分子量 383.6729
分子式 C15H8ClF6NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

100 mM in DMSO; 100 mM in Ethanol
Chemical Name/SMILES

Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-

参考文献

1. Yongmei Feng, et al. Mol Cancer Ther. 2021 May;20(5):816-832.
2. Liu Y, et al. Biochem Biophys Res Commun. 2020 May 7;525(3):589-594.
3. Ogawa H, et al. Clin Exp Allergy. 2011 Jan;41(1):104-15.

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