IMB5476 | Microtubule inhibitor | Probechem Biochemicals

Chemical Structure : IMB5476

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IMB5476 (IMB 5476, IMB-5476)

货号: PC-72275Not For Human Use, Lab Use Only.

IMB5476 (IMB 5476) is a nitrobenzoate microtubule inhibitor, exerts broad-spectrum cytotoxicity against various human tumor cell lines (NCI-H460, IC50=144 nM).

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生物&药学活性

IMB5476 (IMB 5476) is a nitrobenzoate microtubule inhibitor, exerts broad-spectrum cytotoxicity against various human tumor cell lines (NCI-H460, IC50=144 nM).
IMB5476 inhibits purified tubulin polymerization in vitro, binds to tubulin at the colchicine pocket.
IMB5476 induced cell death by mitotic catastrophe and apoptosis, disrupted microtubule networks in cells and arrested cell cycle at G2/M phase.
IMB5476 is a poor substrate of P-glycoprotein and exhibited potent cytotoxicity against drug-resistant tumor cells.
IMB5476 inhibited angiogenesis in vitro, also inhibited the growth of drug-resistant KBV200 xenografts in mice.

物理化学性质&存储条件

分子量	416.818
分子式	C19H17ClN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl 2-morpholino-5-nitrobenzoate

参考文献

1. Yan-Bo Zheng, et al. Eur J Pharmacol. 2022 Feb 8;919:174802.

IMB5476 (IMB 5476, IMB-5476)

生物&药学活性

物理化学性质&存储条件

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IMB5476 (IMB 5476, IMB-5476)

生物&药学活性

物理化学性质&存储条件

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