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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin-IMB5046
IMB5046

Chemical Structure : IMB5046

CAS No.: 1001571-08-9

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IMB5046 (IMB-5046)

货号: PC-24239Not For Human Use, Lab Use Only.

IMB5046 is a novel nitrobenzoate microtubule inhibitor, inhibits tubulin polymerization and shows cytotoxicity against multidrug-resistant cell lines in vitro and in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

IMB5046 is a novel nitrobenzoate microtubule inhibitor, inhibits tubulin polymerization and shows cytotoxicity against multidrug-resistant cell lines in vitro and in vivo.
IMB5046 displayed potent cytotoxicity against multiple tumor cell lines with IC50 of 37-426 nM.
IMB5046 is not a P-glycoprotein substrate.
IMB5046 blocked cell cycle at G2/M phase and induced cell apoptosis.

物理化学性质&存储条件

分子量 388.44
分子式 C19H20N2O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(methylthio)benzyl 2-morpholino-5-nitrobenzoate

参考文献

1. Zheng YB, et al. Sci Rep. 2016 Aug 11;6:31472.

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