IMB0901 | Myostatin inhibitor | Probechem Biochemicals

Chemical Structure : IMB0901

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IMB0901 (IMB 0901)

货号: PC-21391Not For Human Use, Lab Use Only.

IMB0901 is a small molecule myostatin (MSTN) inhibitor that inhibits the MSTN promoter activity, the MSTN signaling pathway, and the MSTN positive feedback regulation.

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生物&药学活性

IMB0901 is a small molecule myostatin (MSTN) inhibitor that inhibits the MSTN promoter activity, the MSTN signaling pathway, and the MSTN positive feedback regulation.
IMB0901 at a concentration of 2.5 or 5 μM significantly neutralized the MSTN signaling pathway triggered by 10 ng/ml MSTN.
IMB0901 at a dose of 5 μM significantly inhibited the P-SMAD and increased the P-FOXO3a in atrophied C2C12 myotubes.
IMB0901 upregulated the expressions of myotube markers and protected the myotube morphology.
IMB0901 lowered the expressions of Atrogin-1, MuRF-1, and ubiquitin and promoted phosphorylation of AKT, mTOR, and P70S6K in atrophied C2C12 myotubes.
IMB0901 (30 mg/kg) inhibited the weight loss of body, quadriceps, and gastrocnemius induced by C26 tumor model, decreased the expression of two E3 ligases Atrogin-1 and MuRF-1 in the quadriceps in vivo.
IMB0901 is a promising leading compound for the management of muscle atrophy induced by cancer cachexia.

物理化学性质&存储条件

分子量	352.22
分子式	C15H15Cl2N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1-(3,4-dichlorophenyl)-1H-pyrazolo [3,4-d] pyrimidin-4-yl) amino) butan-1-ol

参考文献

1. Dong Liu, et al. Skelet Muscle. 2019 Mar 28;9(1):8.

IMB0901 (IMB 0901)

生物&药学活性

物理化学性质&存储条件

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IMB0901 (IMB 0901)

生物&药学活性

物理化学性质&存储条件

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