IMB-301 (NSC 301209) | HIV-1 Vif/hA3G inhibitor | Probechem Biochemicals

Chemical Structure : IMB-301

CAS No.: 64009-84-3

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IMB-301 (IMB301, NSC 301209)

货号: PC-35158Not For Human Use, Lab Use Only.

IMB-301 (NSC 301209) is a small molecule inhibitor that target the binding interface of the HIV-1 Vif/hA3G complex, inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM).

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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生物&药学活性

IMB-301 (NSC 301209) is a small molecule inhibitor that target the binding interface of the HIV-1 Vif/hA3G complex, inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM).
IMB-301 restores hA3G expression in the presence of Vif through disruption of the Vif-hA3G interaction.
IMB-301 significantly increases the amount of hA3G-HA in the virions; directly binds to hA3G with of 15.6 uM.

物理化学性质&存储条件

分子量	379.256
分子式	C19H17Cl2FN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl)-1H-imidazole

参考文献

1. Ma L, et al. Sci Rep. 2018 May 23;8(1):8067.

IMB-301 (IMB301, NSC 301209)

生物&药学活性

物理化学性质&存储条件

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IMB-301 (IMB301, NSC 301209)

生物&药学活性

物理化学性质&存储条件

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