IMA-1 | ALOX12 inhibitor | Probechem Biochemicals

Chemical Structure : IMA-1

加入收藏

IMA-1 (ALOX12-ACC1 inhibitor IMA-1)

货号: PC-72818Not For Human Use, Lab Use Only.

IMA-1 (ALOX12-ACC1 inhibitor IMA-1) is a small molecule that interrupt the arachidonate 12-lipoxygenase (ALOX12)-acetyl-CoA carboxylase 1 (ACC1) interaction.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

IMA-1 is a small molecule that interrupt the arachidonate 12-lipoxygenase (ALOX12)-acetyl-CoA carboxylase 1 (ACC1) interaction.
IMA-1 markedly blocked diet-induced NASH progression in both male mice and Cynomolgus macaque therapeutic models.
The anti-NASH efficacy of IMA-1 was comparable to ACC inhibitor in both species.
IMA-1 directly binds to a pocket in ALOX12 proximal to its ACC1-interacting surface instead of inhibiting ALOX12 lipoxygenase activity.
IMA-1 treatment did not elicit hyperlipidemia, a known side effect of direct inhibition of ACC enzymatic activity, in both mice and macaques.

物理化学性质&存储条件

分子量	617.644
分子式	C27H27N3O10S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S,4S,5R,6S)-6-(2-(((4-(N-(benzo[d]thiazol-2-yl)sulfamoyl)phenyl)amino)methyl)-6-methoxyphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

参考文献

1. Xiao-Jing Zhang, et al. Sci Transl Med. 2021 Dec 15;13(624):eabg8116.

IMA-1 (ALOX12-ACC1 inhibitor IMA-1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

IMA-1 (ALOX12-ACC1 inhibitor IMA-1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.