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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HSV-IM-250
IM-250

Chemical Structure : IM-250

CAS No.: 2305750-23-4

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IM-250 (IM250)

货号: PC-72690Not For Human Use, Lab Use Only.

IM-250 is a potent HSV-1 helicase primase inhibitor, inhibits HSV-1 replication with IC50 of 20 nM (clinical isolate of HSV-1).

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10 mg ￥3980 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IM-250 is a potent HSV-1 helicase primase inhibitor, inhibits HSV-1 replication with IC50 of 20 nM (clinical isolate of HSV-1).
IM-250 dispalys similar IC50 values (20-30 nM) against ACV-resistant HSV-1 clinical isolates 2 and 3 and ACV-resistant HSV-2 clinical isolates 7 and 8.
IM-250 exhibits a broad therapeutic window against HSV-1 in vitro with pronounced higher SI values as obtained for acyclovir (ACV).
IM-250 shows in vivo efficacy and attenuates viral burden in HSV-1 infection mouse model.

物理化学性质&存储条件

分子量 435.51
分子式 C20H19F2N3O2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(2',5'-difluoro-[1,1'-biphenyl]-4-yl)-N-methyl-N-(4-methyl-5-(S-methylsulfonimidoyl)thiazol-2-yl)acetamide

参考文献

1. Uhlig N, et al. Antiviral Res. 2021 Nov;195:105190.

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