IL17A inhibitor 10

Chemical Structure : IL17A inhibitor 10

加入收藏

货号: PC-49281Not For Human Use, Lab Use Only.

IL17A inhibitor 10 is a potent and selective, cell-active inhibitor of IL17A C-terminal region with high binding affinity (SPR KD=43 nM), shows inhibition of IL17A/IL7RA-Fc interactions with IC50 of 740 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

IL17A inhibitor 10 is a potent and selective, cell-active inhibitor of IL17A C-terminal region with high binding affinity (SPR KD=43 nM), shows inhibition of IL17A/IL7RA-Fc interactions with IC50 of 740 nM.
IL17A inhibitor 10 exhibits an IC50 of 107 nM in FP assays when the unlabeled compound was pre-bound to IL17A before addition of FP probe.
IL17A inhibitor 10 inhibits IL17A/TNF stimulated cells in an IL17-dependent cell-based assay in which recombinant TNF and IL17A stimulated HeLa cells carrying an LCN2 promoter-driven luciferase reporter, with a much weaker TNF-only stimulated (IC50>50 uM).

物理化学性质&存储条件

分子量	854.960
分子式	C52H46N4O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,5'-((((((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(2,1-phenylene))bis(methylene))bis(azanediyl))bis(3-(quinolin-4-yl)benzoic acid)

参考文献

1. Eric R. Goedken, et al. Sci Rep. volume 12, Article number: 14561 (2022)