IKK16 |CAS:1186195-62-9 Probechem Biochemicals

Chemical Structure : IKK16

CAS No.: 1186195-62-9

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IKK16 (IKK 16)

货号: PC-63330Not For Human Use, Lab Use Only.

IKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1380	In stock
25 mg	￥2280	In stock
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100 mg		Get quote

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生物&药学活性

IKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively.
IKK16 inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM with IC50 of 1.0, 0.5, 0.3 and 0.3 uM respectively.
IKK16 inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis models.

物理化学性质&存储条件

分子量	535.107
分子式	C28H31ClN6OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride

参考文献

1. Waelchli R, et al. Bioorg Med Chem Lett. 2006 Jan 1;16(1):108-12.

2. Thein S, et al. Biochem Biophys Res Commun. 2014 Jul 18;450(1):550-4.

3. Sordi R, et al. Mol Med. 2015 Jun 18;21:563-75.

4. Liu JC, et al. Cell Rep. 2018 Apr 3;23(1):112-126.

IKK16 (IKK 16)

生物&药学活性

物理化学性质&存储条件

参考文献

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IKK16 (IKK 16)

生物&药学活性

物理化学性质&存储条件

参考文献

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