IITR08367 | Efflux pump AbaF inhibitor | Probechem Biochemicals

Chemical Structure : IITR08367

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IITR08367 (IITR-08367)

货号: PC-22101Not For Human Use, Lab Use Only.

IITR08367 is a potent efflux inhibitor against AbaF in A. baumannii, inhibits efflux pumps by disrupting the proton gradient across the bacterial membrane.

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生物&药学活性

IITR08367 is a potent efflux inhibitor against AbaF in A. baumannii, inhibits efflux pumps by disrupting the proton gradient across the bacterial membrane.
IITR08367 acts by affecting the ΔpH component of the cell.
IITR08367 is effective against clinical strains of A. baumannii.
IITR08367 potentiates fosfomycin activity against A. baumannii RPTC-15.
Combination of fosfomycin and IITR08367 reduces in vivo A. baumannii burden in C. elegans and murine UTI model, does not show any enhanced adverse effect.
IITR08367 is a potent adjuvant for fosfomycin treatment against A. baumannii.

物理化学性质&存储条件

分子量	274.44
分子式	C16H18S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	bis(4-methylbenzyl) disufide

参考文献

1. Mahak Saini, et al. ACS Infect Dis. 2024 Apr 1. doi: 10.1021/acsinfecdis.4c00077.

IITR08367 (IITR-08367)

生物&药学活性

物理化学性质&存储条件

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IITR08367 (IITR-08367)

生物&药学活性

物理化学性质&存储条件

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