IIIM-290 |CAS: 2213468-64-3 Probechem Biochemicals

Chemical Structure : IIIM-290

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IIIM-290 (IIIM290)

货号: PC-62534Not For Human Use, Lab Use Only.

IIIM-290 (IIIM290) is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively.

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生物&药学活性

IIIM-290 (IIIM290) is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively.
IIIM-290 selectively inhibits Molt-4/MIAPaCa-2 cell growth with GI50 of <1 uM.
IIIM-290 inhibits the cell growth of MIAPaCa-2 cells via caspase-dependent apoptosis, demonstrates in vivo efficacy in pancreatic, colon, and leukemia xenografts at 50 mg/kg, po., without CYP/efflux-pump liability, and mutagenic/genotoxic or cardiotoxic effects.

物理化学性质&存储条件

分子量	462.323
分子式	C23H21Cl2NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1'R,2'S)-2-(2,6-Dichlorostyryl)-5,7-dihydroxy-8-(3-hydroxy-1- methylpiperidin-4-yl)-4H-chromen-4-one

参考文献

1. Bharate SB, et al. J Med Chem. 2018 Feb 22;61(4):1664-1687.

IIIM-290 (IIIM290)

生物&药学活性

物理化学性质&存储条件

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IIIM-290 (IIIM290)

生物&药学活性

物理化学性质&存储条件

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