II-B08 |CAS:1143579-78-5 Probechem Biochemicals

Chemical Structure : II-B08

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II-B08 (SHP2 inhibitor II-B08)

货号: PC-61276Not For Human Use, Lab Use Only.

II-B08 is a potent, selective, reversible inhibitor of PTP SHP2 with IC50 of 5.5 uM, exhibits >3-fold selectivity for SHP2 over other PTPs.

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生物&药学活性

II-B08 is a potent, selective, reversible inhibitor of PTP SHP2 with IC50 of 5.5 uM, exhibits >3-fold selectivity for SHP2 over other PTPs.
II-B08 blocks growth factor stimulated ERK1/2 activation and hematopoietic progenitor proliferation.
II-B08 exhibits marked anti-tumor activity in H1975 xenograft mice.

物理化学性质&存储条件

分子量	557.61
分子式	C33H27N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid

参考文献

1. Nabinger SC, et al. Leukemia. 2013 Feb;27(2):398-408.

2. Zhang X, et al. J Med Chem. 2010 Mar 25;53(6):2482-93.

3. Xu J, et al. Biochem Biophys Res Commun. 2013 Oct 4;439(4):586-90.

4. Sharma N, et al. Oncotarget. 2014 Aug 15;5(15):6130-41.

II-B08 (SHP2 inhibitor II-B08)

生物&药学活性

物理化学性质&存储条件

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II-B08 (SHP2 inhibitor II-B08)

生物&药学活性

物理化学性质&存储条件

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