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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Smoothened (Smo)-IHR-1
IHR-1

Chemical Structure : IHR-1

CAS No.: 548779-60-8

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IHR-1 (IHR 1;IHR1)

货号: PC-60380Not For Human Use, Lab Use Only.

A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay; blocks Smo accumulation in the primary cilium without inhibiting SAG-induced pathway response.

物理化学性质&存储条件

分子量 454.13
分子式 C20H12Cl4N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N,N'-(1,4-phenylene)bis(2,5-dichlorobenzamide)

参考文献

1. Fan CW, et al. Chem Biol. 2014 Dec 18;21(12):1680-9.

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