IHCH9033

Chemical Structure : IHCH9033

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货号: PC-23991Not For Human Use, Lab Use Only.

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生物&药学活性

IHCH9033 is a selective, triazole-containing class I HDAC inhibitor, exhibits an increased antitumor effect in FLT3-ITD AML through effectively eliminating leukemia burden and overcoming resistance to FLT3i.
IHCH9033 selectively inhibited DNA repair in FLT3-ITD AML cells, leading to the accumulation of DNA damage that eventually resulted in cell cycle arrest and apoptosis.
IHCH9033 induced HSP90 acetylation, FLT3 ubiquitination, and proteasomal degradation of FLT3, thereby inhibiting FLT3 downstream signaling.
IHCH9033 maintained its potency in both FLT3i-resistant AML cell lines and primary-resistant patient samples, and exerted strong synergy with the FLT3i quizartinib, leading to tumor regression in FLT3-ITD/TKD AML xenografts.

物理化学性质&存储条件

分子量	461.91
分子式	C23H20ClN7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-amino-N-(4-((2-aminophenyl)carbamoyl)benzyl)-2-(2-chlorophenyl)-2H-1,2,3-triazole-4-carboxamide

参考文献

1. Yao M, et al. Exp Hematol Oncol. 2025 Feb 15;14(1):15.

IHCH9033

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物理化学性质&存储条件

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IHCH9033

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物理化学性质&存储条件

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