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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aldehyde Dehydrogenase (ALDH)-IGUANA-5
IGUANA-5

Chemical Structure : IGUANA-5

CAS No.:

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IGUANA-5 (IGUANA 5)

货号: PC-28574Not For Human Use, Lab Use Only.

IGUANA-5 is a potent, selective next-generation ALDH1B1 inhibitor with biochemical IC50 of 13 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

IGUANA-5 is a potent, selective next-generation ALDH1B1 inhibitor with biochemical IC50 of 13 nM.
IGUANA-5 inhibits LDH1A3−/−A375 cells overexpressing ALDH1B1 within 37% in ALDEFLUOR assays.
IGUANA-5 downregulates genes related to mitochondrial respiration (e.g. MT-CO3, MT-CO1, MT-ND5, MT-ND6) in Panc10.05 cells.
IGUANA-5 also significantly upregulates genes involved in cholesterol biosynthesis (e.g. HMGCS1, MSMO1, INSIG1, IDI1, MVD) in pancreatic cancer cells.
IGUANA-5 selectively blocks the growth of colon and pancreatic cancer spheroids and exhibits enhanced in vitro and in vivo pharmacological properties.

物理化学性质&存储条件

分子量 540.59
分子式 C29H31F3N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(3-(4-(Cyclohexyloxy)phenyl)-6,7-dihydroimidazo[1,2-a]pyrimidin-1(5H)-yl)-3-ethylbenzonitrile Trifluoroacetic Acid Salt

参考文献

1. Tarhan AK, et al. J Med Chem. 2026 Oct 22;69(20):23428-23448.

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