IGF2BP3 inhibitor AE-848 | IGF2BP3 inhibitor | Probechem Biochemicals

Chemical Structure : IGF2BP3 inhibitor AE-848

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IGF2BP3 inhibitor AE-848 (AE-848, AE848)

货号: PC-21363Not For Human Use, Lab Use Only.

IGF2BP3 inhibitor AE-848 is a small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), inhibits the growth and progression of OC cells by disrupting the stability of the targeted mRNAs of IGF2BP3.

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生物&药学活性

IGF2BP3 inhibitor AE-848 is a small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), inhibits the growth and progression of OC cells by disrupting the stability of the targeted mRNAs of IGF2BP3.
AE-848 significantly inhibited tumor growth by reducing the expression of tumor-associated antigen (c-MYC/VEGF/Ki67/CDK2) and improving the anti-tumor effect of macrophages.
AE-848 not only could duplicate the above results of knockdown assay but also reduces the expression of c-MYC in M2 macrophages and tumor-associated macrophages and promotes the cytokine IFN-γ and TNF-α secretion.

物理化学性质&存储条件

分子量	738.95
分子式	C40H50N8O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2,4-di-tert-pentylphenoxy)-N-(4-(3-morpholino-5-oxo-4-((1-phenyl-1H-tetrazol-5-yl)thio)-4,5-dihydro-1H-pyrazol-1-yl)phenyl)butanamide

参考文献

1. Chang Shu, et al. Am J Cancer Res. 2023 Oct 15;13(10):4888-4902.

IGF2BP3 inhibitor AE-848 (AE-848, AE848)

生物&药学活性

物理化学性质&存储条件

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IGF2BP3 inhibitor AE-848 (AE-848, AE848)

生物&药学活性

物理化学性质&存储条件

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