IGF2BP2 inhibitor JX5 | IGF2BP2 inhibitor | Probechem Biochemicals

Chemical Structure : IGF2BP2 inhibitor JX5

CAS No.: 301207-96-5

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IGF2BP2 inhibitor JX5 (JX5)

货号: PC-49190Not For Human Use, Lab Use Only.

IGF2BP2 inhibitor JX5 is a specific small-molecule inhibitor of N6-methyladenosine (m6A) reader insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) with Kd of 93.2 uM in internal fluorescence quenching measurement assays, suppresses T-ALL cells proliferation via downregulation of NOTCH1 expression.

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生物&药学活性

IGF2BP2 inhibitor JX5 is a specific small-molecule inhibitor of N6-methyladenosine (m6A) reader insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) with Kd of 93.2 uM in internal fluorescence quenching measurement assays, suppresses T-ALL cells proliferation via downregulation of NOTCH1 expression.
JX5 showed dramatic cytotoxicity against Jurkat cells with IGF2BP2 overexpression, with minor effects on Jurkat cells transduced with IGF2BP2 shRNA. caused cell apoptosis on Jurkat cells.
JX5 has no effect on the IGF2BP2 mRNA levels but significantly down regulated the NOTCH1 expression.
JX5 (1 mg/kg or 2 mg/kg) by intraperitoneal injection impaired T-ALL expansion in T-ALL xenografts, with no overt toxicity or effect on mouse body weight and gastrointestinal system

物理化学性质&存储条件

分子量	580.604
分子式	C34H24N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2H-benzo[d][1,2,3]triazol-2-yl)-4-methylphenyl (3-(2H-benzo[d][1,2,3]triazol-2-yl)-4-methylphenyl) isophthalate

参考文献

1. Panpan Feng, et al. Leukemia. 2022 Aug 1. doi: 10.1038/s41375-022-01651-9.

IGF2BP2 inhibitor JX5 (JX5)

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物理化学性质&存储条件

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IGF2BP2 inhibitor JX5 (JX5)

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